| Sandraen | Дата: Суббота, 04-07-2015, 05:46 | Сообщение # 1 |
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Celecoxib (Celebrex) Linked to Multiple Adverse Events
On July 29, the FDA approved protection labeling revisions seeing that the nonsteroidal anti-inflammatory (NSAID) drug celecoxib (Celebrex capsules, made nearby Pfizer Global Pharmaceuticals) to tip off of contraindications and warnings associated with this class of drugs and to emphasize the stress to disparage its use to the lowest effective measure because the shortest conceivable duration.
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Exploit of a NSAID similar to celecoxib in support of suffering running during the maiden 10 to 14 days after coronary artery bypass corruption (CABG) surgery has been linked to an increased risk for myocardial infarction (MI) and slam; use of celecoxib in this setting is accordingly contraindicated.
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The FDA also warned that persistent need of celecoxib may be linked to an increased chance for grave and potentially fateful cardiovascular thrombotic events, MI, and stroke. As with other NSAIDs, these risks may snowball in the adjacency of existing cardiovascular infirmity and/or related risk factors.
The example was based on results of the Bar of Intermittent Colorectal Adenomas with Celecoxib venture in 1,356 patients, showing that profit by of 400 mg of celecoxib twice daily was linked to a 3.4-fold proliferate in the composite chance of cardiovascular death, MI, or stitch, applicable to placebo (95% self-confidence meantime [CI - , 1.4 - 8.5). In patients receiving 200 mg of celecoxib twice always, the analogous to imperil was 2.4 (95% CI, 1.0 - 6.4).
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The FDA notes that there is no steadfast verification that concurrent use of low-dose aspirin mitigates the increased chance for dangerous cardiovascular thrombotic events associated with celecoxib use.
Also, materials from the Celecoxib Long-Term Arthritis Safe keeping Ruminate on (CATEGORY) of 8,000 patients bear linked concomitant utilization of low-dose aspirin and 400 mg of celecoxib twice always to an increased risk during sombre gastrointestinal adverse events compared with celecoxib unexcelled (2.19% vs 0.78%). This endanger was extra increased in the ancient (3.06% vs 1.40%).
A 400-mg administer of celecoxib twice regularly is twofold and fourfold the recommended amount for rheumatoid arthritis and osteoarthritis, each to each, and the approved administer for familial adenomatous polyposis.
Aqueous retention and edema have also been observed in patients receiving NSAIDs, such as celecoxib. In the BIRTH chew over, the Kaplan-Meier cumulative rates of unimportant edema at nine months in patients receiving 400 mg of celecoxib twice daily, 800 mg of ibuprofen three times daily, and 75 mg of diclofenac twice daily were 4.5%, 6.9%, and 4.7%, respectively.
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The FDA advises that celecoxib be prescribed with care in patients with unformed retention or pith failure. Because concurrent use of NSAIDs may mar return to treatment with thiazides or circle diuretics, close monitoring of blood adversity is recommended.
In the FORM study, hypertension was observed in 2.4%, 4.2%, and 2.5%, mutatis mutandis, in patients receiving celecoxib, ibuprofen, and diclofenac.
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Celecoxib and other NSAIDs are also associated with an increased jeopardize for serious and potentially fateful gastrointestinal adverse events, particularly in the elderly. Bleeding, ulceration, and perforation of the spare tyre or intestines may manifest itself at any eventually during analysis and without threat symptoms; just equal in five patients who improve a crucial blue bloods gastrointestinal tract adverse episode while receiving NSAID cure is symptomatic.
The FDA notes that the endanger of developing a gastrointestinal bleed is 10-fold greater in patients with a whilom before history of peptic poison affliction and/or gastrointestinal bleeding, and NSAIDs should thus be prescribed with extreme discretion in this population.
Other factors that multiply the risk of bleeding catalogue concomitant exhaust of oral corticosteroids, anticoagulants, longer duration of cure, smoking, moonshine consumption, advanced adulthood, and short general robustness status. Because most unguarded reports of poisonous gastrointestinal events are in elderly or debilitated patients, special tend should be taken in treating this population.
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Papillary necrosis and other renal injuries include been observed with long-term administration of celecoxib and other NSAIDs. In patients for whom renal prostaglandins maintain a remunerative role in the conservation of renal perfusion, NSAIDs may provoke a dose-dependent reduction in prostaglandin institution that may press visible renal decompensation.
Patients with impaired renal function, courage nonentity, liver dysfunction, the ageing, and those fascinating diuretics and angiotensin-converting enzyme inhibitors are at greatest imperil in requital for this reaction. Discontinuation of NSAID therapy is in the main followed by way of rescue to the pretreatment state.
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| Dentalpt | Дата: Среда, 08-02-2017, 17:48 | Сообщение # 2 |
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| Кто нибудь делал себе имплантацию зубов? Знаешь Аггей, я вот что узнал. Имплантация зубов в Москве, как и во всех развитых городах, стала успешной альтернативой протезированию коронками . Восстановить утраченные зубы, а вместе с ними и вкус к жизни в любом возрасте поможет современная стоматологическая процедура имплантации зубов в Москве. У меня возник вопрос: Как определить рейтинг стоматологий, где лучше устанавливать импланты?. Думаю более подробно можно почитать это: https://dentalgu.ru/ - имплантация зубов клиники москва.
Существует множество материалов, благодаря которым художественная реставрация зубов в Москве может быть выполнена в короткий срок, подробнее почитайте это - https://dentalgu.ru/restavratsiya-zubov/ - реставрация зубов композитным материалом цена .
Алистратов Мирон:
Какое протезирование зубов лучше? Выбор способа протезирования зубов зависит от конкретного клинического случая и финансовых возможностей, подробно протезирование можно прочитать это - https://dentalgu.ru/protezirovanie-zubov/ - протезирования зубов недорого цены ,
https://dentalgu.ru/kostnaya-plastika/ - костная пластика челюстей виды и причины дефектов нижней челюсти.
А вот какие я еще нашел интересные статьи на эту тему:
http://sport-kosa.ru/vsyakoe-raznoe/implantaciya-i-protezirovanie-zubov-v-dental-guru.html - Имплантация и протезирование зубов в «Дентал Гуру»
http://surgeryzone.net/info/informaciya-po-chelyustno-licevoj-xirurgii-i-stomatologii/preimushhestva-implantacii-zubov.html - Преимущества имплантации зубов
http://tltgorod.ru/article/theme-3/news-1169/ - Имплантация зубов: подготовка и диагностика
Гнилорыбов Агафон:
А эти статьи про стоматологию думаю полезно прочитать каждому:
https://dentalgu.ru/statyi/implantatsiya-zubov/odnomomentnaya-implantatsiya-zubov/ - Одномоментная имплантация зубов
https://dentalgu.ru/statyi/otbelivanie-zubov/otbelivanie-zubov-sistemoy-zoom/ - Отбеливание зубов системой Zoom
https://dentalgu.ru/statyi/lechenie-zubov/lechenie-zubov-pod-obshchim-narkozom/ - Лечение зубов под общим наркозом
Реставрация зубов фотополимерами цена http://dentalgu.ru/
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| Tamaraveni | Дата: Среда, 29-03-2017, 15:06 | Сообщение # 3 |
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| EvseyDon | Дата: Пятница, 07-04-2017, 12:32 | Сообщение # 4 |
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